SCIENTIFIC PUBLICATIONS

Banga R., Rebecchini C., Procopio FA., Noto A., Munoz O., Ioannidou K., Fenwick C., Ohmiti K., Cavassini M., Corpataux JM., de Leval L., Pantaleo G., Perreau M.

Lymph node migratory dendritic cells modulate HIV-1 transcription through PD-1 engagement

Fenwick C., Loredo-Varela JL., Joo V., Pellaton C., Farina A., Rajah N., Esteves-Leuenberger L., Decaillon T., Suffiotti M., Noto A., Ohmiti K., Gottardo R., Weissenhorn W., Pantaleo G.

Tumor suppression of novel anti-PD-1 antibodies mediated through CD28 costimulatory pathway.

Amelio P., Portevin D., Hella J., Reither K., Kamwela L., Lweno O., Tumbo A., Geoffrey L., Ohmiti K., Ding S., Pantaleo G., Daubenberger C., Perreau M.

HIV Infection Functionally Impairs Mycobacterium tuberculosis-specific CD4 and CD8 T-cell responses

Cheng L., Wang Q., Li G., Banga R., Ma J., Yu H., Yasui F., Zhang Z., Pantaleo G., Perreau M., Zurawski S., Zurawski G., Levy Y., Su L..

TLR3 agonist and CD40-targeting vaccination induces immune responses and reduces HIV-1 réservoirs.

Yates NL., deCamp AC., Korber BT., Liao HX., Irene C., Pinter A., Peacock J., Harris LJ., Sawant S., Hraber P., Shen X., Rerks-Ngarm S., Pitisuttithum P., Nitayapan S., Berman P., Robb ML., Pantaleo G., Zolla-Pazner S., Haynes BF., Alam SM., Montefiori DC., Tomaras GD.

HIV-1 Envelope Glycoproteins from Diverse Clades Differentiate Antibody Responses and Durability among Vaccinees.

Saunders KO., Santra S., Parks R., Yates NL., Sutherland LL., Scearce RM., Balachandran H., Bradley T., Goodman D., Eaton A., Stanfield-Oakley SA., Tartaglia J., Phogat S., Pantaleo G., Esteban M., Gomez CE., Perdiguero B., Jacobs B., Kibler K., Korber B., Montefiori DC., Ferrari G., Vandergrift N., Liao HX., Tomaras GD., Haynes BF..

Immunogenicity of NYVAC Prime-Protein Boost Human Immunodeficiency Virus Type 1 Envelope Vaccination and Simian-Human Immunodeficiency Virus Challenge of Nonhuman Primates.

Noto A., Procopio FA., Banga R., Suffiotti M., Corpataux JM., Cavassini M., Fenwick C., Gottardo R., Perreau M., Pantaleo G.

CD32 and PD-1 Lymph Node CD4 T Cells Support Persistent HIV-1 Transcription in Treated Aviremic Individuals.

Perreau M., Banga R., Pantaleo G..

Targeted Immune Interventions for an HIV-1 Cure.

Chatziandreon N., Farsakoglu Y., Palomino-Segura M., D’Anguono R., Pizzagalli DU., Sallusto F., Lukacs-Kornek V., Ugoccioni M., Corti D., Turley SJ., Lanzavecchia A., Carroll MC., Gonzalez SF.

Macrophage Death following Influenza Vaccination Initiates the Inflammatory Response that Promotes Dendritic Cell Function in the Draining Lymph Node Cell Rep. 2017 Mar 7;18(10):2427-2440

Amelio P., Portevin D., Reither K., Mhimbira F., Mpina M., Tumbo A., Nickel B., Marti H., Knopp S., Ding S., Penn-Nicholson A., Darboe F., Ohmiti K., Scriba TJ., Pantaleo G., Daubenberger C., Perreau M.

Mixed Th1 and Th2 Mycobacterium tuberculosis-specific CD4 T cell responses in patients with active pulmonary tuberculosis from Tanzania.

Shen X, Dojcinovic D, Baldi L, Hacker DL, Luescher IF, Wurm FM.

Improved process conditions for increasing expression of MHC class II protein from a stable Drosophila S2 cell line. Biotechnol Lett.

Rajendra Y, Balasubramanian S, Hacker DL.

Large-Scale Transient Transfection of Chinese Hamster Ovary Cells in Suspension. Methods Mol Biol.

Lee RFS, Chernobrovkin A, Rutishauser D, Allardyce CS, Hacker D, Johnsson K, Zubarev RA, Dyson PJ.

Expression proteomics study to determine metallodrug targets and optimal drug combinations.

Utzschneider DT., Charmoy M., Chennupati V., Pousse L., Ferreira DP., Calderon-Copete S., Danilo M., Alfei F., Jofmann M., Wieland D., Pradervand S., Thimme R., Zehn D., Held W.

T Cell Factor 1-Expressing Memory-like CD8(+) T Cells Sustain the Immune Response to Chronic Viral Infections. Immunity. 2016 Aug 16;45(2):415-27.

Utzschneider DT., Alfei F., Roelli P., Barras D., Chennupati V., Darbre S., Delorenzi M., Pinschewer DD., Zehn D.

High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival. J Exp Med. 2016 Aug 22;213(9):1819-34.

Tan J., Pieper K., Piccoli L., Abdi A., Foglierini M., Geiger R., Tully CM., Jarrossay D., Ndungu FM., Wambua J., Bejon P., Fregni CS., Fernandez-Rodriguez B., Barbieri S., Bianchi S., Marsh K., Thathy V., Corti D., Sallusto F., Bull P., Lanzavecchia A.

A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens Nature. 2016 Jan 7;529(7584):105-9

Segal G., Prato S., Zehn D., Mintern JD., Villadangos JA.

Target Density, Not Affinity or Avidity of Antigen Recognition, Determines Adoptive T Cell Therapy Outcomes in a Mouse Lymphoma Model. J Immunol. 2016 May 1;196(9):3935-42.

Rusert P., Kouyos RD., Kadelka C., Ebner H., Schanz M., Huber M., Braun DL., Hozé N., Scherrer A., Magnus C., Weber J., Uhr T., Cippa V., Thorball CW., Kuster H., Cavassini M., Bernasconi E., Hoffmann M., Calmy A., Battegay M., Rauch A., Yerly S., Aubert V., Klimkait T., Böni J., Fellay J., Regoes RR., Günthard HF., Trkola A., Swiss HIV Cohort Study.

Determinants of HIV-1 broadly neutralizing antibody induction Nat Med. 2016 Nov;22(11):1260-1267

Pantaleo G., Levy Y.

Therapeutic vaccines and immunological intervention in HIV infection: a paradigm change Curr Opin HIV AIDS. 2016 Nov;11(6):576-584

Ozga AJ., Moalli F., Abe J., Swoger J., Sharpe J., Zehn D., Kreutzfeldt M., Merkler D., Ripoll J., Stein JV.

pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion. J Exp Med. 2016 Nov 14;213(12):2811-2829. Epub 2016 Oct 31.

Oberle SG., Hanna-El-Daher L., Chennupati V., Enouz S., Scherer S., Prlic M., Zehn D.

A Minimum Epitope Overlap between Infections Strongly Narrows the Emerging T Cell Repertoire. Cell Rep. 2016 Oct 11;17(3):627-635.

Margaroli C., Oberle S., Lavanchy C., Scherer S., Rosa M., Strasse A., Pellegrini M., Zehn D., Acha-Orbea H., Ehirchiou D.

Role of proapoptotic BH3-only proteins in Listeria monocytogenes infection. Eur J Immunol. 2016 Jun;46(6):1427-37.

Münz C.

Epstein Barr virus - a tumor virus that needs cytotoxic lymphocytes to persist asymptomatically. Curr Opin Virol. 2016 Oct;20:34-39

Ludigs K., Jandus C., Utzschneider DT., Staehli F., Bessoles S., Dang AT., Rota G., Castro W., Zehn D., Vivier E., Held W., Romero P., Guarda G.

NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions. Nat Commun. 2016 Feb 10;7:10554.

Lanzavecchia A., Frühwirth A., Perez L., Corti D.

Antibody-guided vaccine design: identification of protective epitopes Curr Opin Immunol. 2016 Aug;41:62-7

Geiger R., Rieckmann JC., Wolf T., Basso C., Feng Y., Fuhrer T., Kogadeeva M., Picotti P., Meissner F., Mann M., Zamboni N., Sallusto F., Lanzavecchia A.

L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. Cell. 2016 Oct 20;167(3):829-842.e13

De Benedictis P., Minola A., Rota Nodari E., Aiello R., Zecchin B., Salomoni A., Foglierini M., Agatic G., Vanzetta F., Lavenir R., Lepelletier A., Bentley E., Weiss R., Cattoli G., Capua I., Sallusto F., Wright E., Lanzavecchia A., Bourhy H., Corti D.

Development of broad-spectrum human monoclonal antibodies for rabies post-exposure prophylaxis. EMBO Mol Med. 2016 Apr 1;8(4):407-21

Chijioke O., Landtwing V., Münz C.

NK Cell Influence on the Outcome of Primary Epstein-Barr Virus Infection. Front Immunol. 2016 Aug 29;7:323

Chennupati V., Koch U., Coutaz M., Scarpellino L., Tacchini-Cottier F., Luther SA., Radtke F., Zehn D., MacDonald HR.

Notch Signaling Regulates the Homeostasis of Tissue-Restricted Innate-like T Cells. J Immunol. 2016 Aug 1;197(3):771-82.

Banga R., Procopio FA., Noto A., Pollakis G., Ohmiti K., Corpataux JM., de Leval L., Pantaleo G., Perreau M.

PD-1(+) and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals.

Utzschneider DT., Alfei F., Roelli P., Barras D., Chennupati V., Darbre S., Delorenzi M., Pinschewer DD., Zehn D.

High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival. J Exp Med. 2016 Aug 22;213(9):1819-34.

Myburgh R., Ivic S., Pepper MS., Gers-Huber G., Li D., Audigé A., Rochat MA., Jaquet V., Regenass S., Manz MG., Salmon P., Krause KH., Speck RF.

Lentivector Knockdown of CCR5 in Hematopoietic Stem and Progenitor Cells Confers Functional and Persistent HIV-1 Resistance in Humanized Mice J Virol. 2015 Jul;89(13):6761-72

Münz C.

EBV Infection of Mice with Reconstituted Human Immune System Components. Curr Top Microbiol Immunol. 2015;391:407-23

Lin L, Finak G, Ushey K, Seshadri C, Hawn TR, Frahm N, Scriba TJ, Mahomed H, Hanekom W, Bart PA, Pantaleo G, Tomaras GD, Rerks-Ngarm S, Kaewkungwal J, Nitayaphan S, Pitisuttithum P, Michael NL, Kim JH, Robb ML, O’Connell RJ, Karasavvas N, Gilbert P, C De Rosa S, McElrath MJ, Gottardo R.

COMPASS identifies T-cell subsets correlated with clinical outcomes Nat Biotechnol. 2015 Jun;33(6):610-6

Li D., Schlaepfer E., Audigé A., Rochat MA., Ivic S., Knowlton CN., Kim B., Keppler OT., Speck RF.

Vpx mediated degradation of SAMHD1 has only a very limited effect on lentiviral transduction rate in ex vivo cultured HSPCs Stem Cell Res. 2015 Sep;15(2):271-80

Jung J., Münz C.

Immune control of oncogenic γ-herpesviruses Curr Opin Virol. 2015 Oct;14:79-86

Gujer C., Chatterjee B., Landtwing V., Raykova A., McHugh D., Münz C.

Animal models of Epstein Barr virus infection Curr Opin Virol. 2015 Aug;13:6-10

Gregorovic G., Boulden EA., Bosshard R., Elgueta Karstegl C., Skalsky R., Cullen BR., Gujer C., Rämer P., Münz C., Farrel PJ.

Epstein-Barr Viruses (EBVs) Deficient in EBV-Encoded RNAs Have Higher Levels of Latent Membrane Protein 2 RNA Expression in Lymphoblastoid Cell Lines and Efficiently Establish Persistent Infections in Humanized Mice. J Virol. 2015 Nov;89(22):11711-4

Corti D., Zhao J., Pedotti M., Simonelli L., Agnihothram S., Fett C., Fernandez-Rodriguez B., Foglierini M., Agatic G., Vanzetta F., Gopal R., Langrish CJ., Barrett NA., Sallusto F., Baric RS., Varani L., Zambon M., Perlman S., Lanzavecchia A.

Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10473-8

Corey L., Gilbert PB., Tomaras GD., Haynes BF., Pantaleo G., Fauci AS.

Immune correlates of vaccine protection against HIV-1 acquisition Sci Transl Med. 2015 Oct 21;7(310):310rv7

Chijioke O., Marcenaro E., Moretta A., Capaul R., Münz C.

Role of the 2B4 Receptor in CD8+ T-Cell-Dependent Immune Control of Epstein-Barr Virus Infection in Mice With Reconstituted Human Immune System Components J Infect Dis. 2015 Sep 1;212(5):803-7

Campos N., Myburgh R., Garcel A., Vautrin A., Lapasset L., Nadal ES., Mahuteau-Betzer F., Najman R., Fornarelli P., Tantale K., Basyuk E., Séveno M., Venables JP., Pau B., Bertrand E., Wainberg MA., Speck RF., Scherrer D., Tazi J.

Long lasting control of viral rebound with a new drug ABX464 targeting Rev - mediated viral RNA biogenesis Retrovirology. 2015 Apr 9;12:30

Kübler A., Woiterski J., Witte KE., B¨hring HJ., Hartwig UF., Ebinger M., Oevermann L., Mezger M., Herr W., Lang P., Handgretinger R., Münz C., André MC:

Both mature KIR+ and immature KIR- NK cells control pediatric acute B-cell precursor leukemia in NOD.Cg-Prkdcscid IL2rgtmWjl/Sz mice. Blood. 2014 Dec 18;124(26):3914-23

Boudousquié C., Danilo M., Pousse L., Jeevan-Raj B., Angelov G.S., Chennupati V., Zehn D., Held W.

Differences in the transduction of canonical Wnt signals demarcate effector and memory CD8 T cells with distinct recall proliferation capacity J. Immunol. 2014, 193:2784-91

Speider DE., Utzschneider DT., Oberle SG., Münz C., Romero P., Zehn D.

T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion? Nat Rev Immunol. 2014 Nov;14(11):768-74

Bart PA., Huang Y., Karuna ST., Chappuis S., Gaillard J., Kochar N., Shen X., Allen MA., Ding S., Hural J., Liao HX., Haynes BF., Graham BS., Gilbert PB., McElrath MJ., Montefiori DC., Tomaras GD., Pantaleo G., Frahm N.

HIV-specific humoral responses benefit from stronger prime in phase Ib clinical trial J Clin Invest. 2014 Nov;124(11):4843-56

Myburgh R., Cherpin O., Schlaepfer E., Rehrauer H., Speck RF., Krause KH., Salmon P.

Optimization of Critical Hairpin Features Allows miRNA-based Gene Knockdown Upon Single-copy Transduction. Mol Ther Nucleic Acids. 2014 Oct 28;3:e207

Azzi T, Lünemann A, Murer A, Ueda S, Béziat V, Malmberg KJ, Staubli G, Gysin C, Berger C, Münz C, Chijioke O, Nadal D

Role for early-differentiated natural killer cells in infectious mononucleosis Blood. 2014 Oct 16;124(16):2533-43

Zehn D., Roepke S., Weakly K., Bevan M.J. and Prlic M.

Inflammation and TCR signal strength determine the breadth of the T cell response in a bim-dependent manner. J. Immunol. 2014, 192:200-205.

Wu D.J., Zhou W., Enouz S., Orrú V., Stanford S.M., Maine C.J., Rapini N., Sawatzke K., Engel I., Fiorillo E., Sherman L.A., Kronenberg M., Zehn D., Peterson E. and Bottini N.

Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells. PLoS One 2014, 9:e86677.

Wiede F., Ziegler A., Zehn D., Tiganis T.

PTPN2 restrains CD8(+) T cell responses after antigen cross-presentation for the maintenance of peripheral tolerance in mice. J. Autoimmun. 2014, 53:105-14

Speiser D.E., Utzschneider D.T., Oberle S.G., Münz C., Romero P., Zehn D.

T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion ? Nat Rev Immunol. 2014, 14:768-74

Münz C.

Viral infections in mice with reconstituted human immune system components Immunol Lett. 2014 Sep;161(1):118-24

Münz C.

Role of human natural killer cells during Epstein-Barr virus infection. Crit Rev Immunol. 2014;34(6):501-7

Koehli S., Naeher D., Galati-Fournier V., Zehn D., Palmer E.

Optimal T-cell receptor affinity for inducing autoimmunity Proc Natl Acad Sci U.S.A. 2014, 111:17248-53

Keck S., Schmaler M., Ganter S., Wyss L., Oberle S., Huseby E.S., Zehn D., King C.G.

Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation Proc Natl Acad Sci U.S.A. 2014, 111:14952-7

Antsiferova O., Müller A., Rämer PC., Chijioke O., Chatterjeee B., Raykova A., Planas R., Sospedra M., Shumilov A., Tsai MH., Delecluse HJ., Münch C.

Adoptive transfer of EBV specific CD8+ T cell clones can transiently control EBV infection in humanized mice PLoS Pathog. 2014 Aug 28;10(8):e1004333

Chatterjee B., Leung CS., Münz C.

Animal models of Epstein Barr virus infection J Immunol Methods. 2014 Aug;410:80-7

Münz C.

Dendritic cells during Epstein Barr virus infection Front Microbiol. 2014 Jun 20;5:308

Salguero G., Daenthanasanmak A., Münz C., Raykova A., Guzmán CA., Riese P., Figueiredo C., Länger F., Schneider A., Macke L., Sundarasetty BS., Witte T., Ganser A., Stripecke R.

Dendritic cell-mediated immune humanization of mice: implications for allogeneic and xenogeneic stem cell transplantation J Immunol. 2014 May 15;192(10):4636-47

Rickinson AB., Long HM., Palendira U., Münz C., Hislop AD.

Cellular immune controls over Epstein-Barr virus infection: new lessons from the clinic and the laboratory Trends Immunol. 2014 Apr;35(4):159-69

Jandus C., Boligan KF., Chijioke O., Liu H., Dahlhaus M., Démoulins T., Schneider C., Wehrli M., Hunger RE., Baerlocher GM., Simon HU., Romero P., Münz C., von Gunten S.

Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance J Clin Invest. 2014 Apr;124(4):1810-20

Viganò S., Bellutti Enders F., Miconnet I., Cellerai C., Savoye A.-L., Rozot V., Perreau M., Faouzi M., Ohmiti K., Cavassini M., Bart P.-A., Pantaleo G. and Harari A.

Rapid perturbation in viremia levels drives increases in functional avidity of HIV-specific CD8 T cells. PLoS Pathog. 2013, 9:e1003423.

Utzschneider D.T., Legat A., Fuertes Marraco S.A., Carrié L., Luescher I., Speiser D.E. and Zehn D.

T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion. Nat. Immunol. 2013, 14:603-610.

Stark R., Hartung A., Zehn D., Frentsch M. and Thiel A.

IL-12-mediated STAT4 signaling and TCR signal strength cooperate in the induction of CD40L in human and mouse CD8+ T cells. Eur. J. Immunol. 2013, 43:1511-1517.

Simonelli L., Pedotti M., Beltramello M., Livoti E., Calzolai L., Sallusto F., Lanzavecchia A., Varani L.

Rational engineering of a human anti-dengue antibody through experimentally validated computational docking PLoS One. 2013;8(2):e55561

Rozot V., Vigano S., Mazza-Stalder J., Idrizi E., Day C.L., Perreau M., Lazor-Blanchet C., Petruccioli E., Hanekom W., Goletti D., Bart P.-A., Nicod L., Pantaleo G. and Harari A.

Mycobacterium tuberculosis-specific CD8+ T cells are functionally and phenotypically different between latent infection and active disease. Eur. J. Immunol. 2013, 43:1568-1577.

Perreau M., Savoye A.-L., De Crignis E., Corpataux J.-M., Cubas R., Haddad E.K., De Leval L., Graziosi C. and Pantaleo G.

Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production. J. Exp. Med. 2013, 210:143-156.

Perreau M., Rozot V., Welles H.C., Belluti-Enders F., Vigano S., Maillard M., Dorta G., Mazza-Stalder J., Bart P.A., Roger T., Calandra T., Nicod L. and Harari A.

Lack of Mycobacterium tuberculosis-specific interleukin-17A-producing CD4+ T cells in active disease. Eur. J. Immunol. 2013, 43:939-948.

Perreau M., Levy Y. and Pantaleo G.

Immune response to HIV. Curr. Opin. HIV AIDS 2013, 8:333-340.

Pantaleo G. and Lévy Y.

Vaccine and immunotherapeutic interventions. Curr. Opin. HIV AIDS 2013, 8:236-242.

Mosconi I., Geuking M.B., Zaiss M.M., Massacand J.C., Aschwanden C., Kwong Chung C.K., McCoy K.D. and Harris N.L.

Intestinal bacteria induce TSLP to promote mutualistic T-cell responses. Mucosal Immunol. 2013, 6:1157-1167.

Legat A., Speiser D.E., Pircher H., Zehn D. and Fuertes Marraco S.A.

Inhibitory receptor expression depends more dominantly on differentiation and activation than "Exhaustion" of human CD8 T cells. Front. Immunol. 2013, 4:455.

Hebeisen M., Oberle S.G., Presotto D., Speiser D.E., Zehn D. and Rufer N.

Molecular insights for optimizing T cell receptor specificity against cancer. Front Immunol. 2013, 4:154.

Dudda J.C., Salaun B., Ji Y., Palmer D.C., Monnot G.C., Merck E., Boudousquie C., Utzschneider D.T., Escobar T.M., Perret R., Muljo S.A., Hebeisen M., Rufer N., Zehn D., Donda A., Restifo N.P., Held W., Gattinoni L. and Romero P.

MicroRNA-155 is required for effector CD8(+) T cell responses to virus infection and cancer. Immunity 2013, 38:742-753.

Cubas R.A., Mudd J.C., Savoye A.-L., Perreau M., van Grevenynghe J., Metcalf T., Connick E., Meditz A., Freeman G.J., Abesada-Terk Jr G., Jacobson J.M., Brooks A.D., Crotty S., Estes J.D., Pantaleo G., Lederman M.M. and Haddad E.K.

Inadequate T follicular cell help impairs B cell immunity during HIV infection. Nat. Med. 2013, 19:494-499.

Chu T., Tyznik A.J., Roepke S., Berkley A.M., Woodward-Davis A., Pattacini L., Bevan M.J., Zehn D. and Prlic M.

Bystander-activated memory CD8 T cells control early pathogen load in an innate-like, NKG2D-dependent manner. Cell Rep. 2013, 3:701-708.

Bioley G., Zehn D., Lassus A., Terrettaz J., Tranquart F. and Corthésy B.

The effect of vaccines based on ovalbumin coupled to gas-filled microbubbles for reducing infection by ovalbumin-expressing Listeria monocytogenes. Biomaterials 2013, 34:5423-5430.

Zehn D., King C., Bevan M.J. and Palmer E.

TCR signaling requirements for activating T cells and for generating memory. Cell. Mol. Life Sci. 2012, 69:1565-1575.

Viganò S., Utzschneider D.T., Perreau M., Pantaleo G., Zehn D. and Harari A.

Functional avidity: a measure to predict the efficacy of effector T cells ? Clin. Dev. Immunol. 2012, 2012:153863.

Viganò S., Perreau M., Pantaleo G. and Harari A.

Positive and negative regulation of cellular immune responses in physiologic conditions and diseases. Clin. Dev. Immunol. 2012, 2012:485781.

Perreau M., Welles H.C., Pellaton C., Gjoksi B., Potin L., Martin R., Harari A., Bett A., Casimiro D., Gall J., Barouch D.H., Kremer E.J., and Pantaleo G.

The number of Toll-like receptor 9-agonist motifs in the adenovirus genome correlates with induction of dendritic cell maturation by adenovirus immune complexes. J. Virol. 2012, 86:6279-6285.

Perreau M., Welles H.C., Harari A., Calandra T., Roger T. and Pantaleo G.

Modulation of human memory T-cell function by different antigen-presenting cells. Eur. J. Immunol. 2012, 42:799-802.

Pattacini L., Mize G.J., Graham J.B., Fluharty T.R., Graham T.M., Lingnau K., Wizel B., Perdiguero B., Esteban M., Pantaleo G., Shen M., Spies G.A., McElrath M.J. and Lund J.M.

A novel HIV vaccine adjuvanted by IC31 induces robust and persistent humoral and cellular immunity. PLoS One 2012, 7:e42163.

McNerney R., Maeurer M., Abubakar I., Marais B., McHugh T.D., Ford N., Weyer K., Lawn S., Grobusch M.P., Memish Z., Squire S.B., Pantaleo G., Chakaya J., Casenghi M., Migliori G.B., Mwaba P., Zijenah L., Hoelscher M., Cox H., Swaminathan S., Kim P.S., Schito M., Harari A., Bates M., Schwank S., O’Grady J., Pletschette M., Ditui L., Atun R. and Zumla A.

Tuberculosis diagnostics and biomarkers: needs, challenges, recent advances, and opportunities. J. Infect. Dis. 2012, 205 Suppl 2:S147-158.

King C.G., Koehli S., Hausmann B., Schmaler M., Zehn D. and Palmer E.

T cell affinity regulates asymmetric division, effector cell differentiation, and tissue pathology. Immunity 2012, 37:709-720.

Jilek S., Schluep M., Harari A., Canales M., Lysandropoulos A., Zekeridou A., Pantaleo G. and Du Pasquier R.A.

HLA-B7-restricted EBV-specific CD8+ T cells are dysregulated in multiple sclerosis. J. Immunol. 2012, 188:4671-4680.

Herbst T., Esser J., Prati M., Kulagin M., Stettler R., Zaiss M.M., Hewitson J.P., Merky P., Verbeek J.S., Bourquin C., Camberis M., Prout M., Maizels R.M., Le Gros G. and Harris N.L.

Antibodies and IL-3 support helminth-induced basophil expansion. Proc. Natl. Acad. Sci. USA 2012, 109:14954-14959.

Harari A., Rozot V., Cavassini M., Enders F.B., Vigano S., Tapia G., Castro E., Burnet S., Lange J., Moog C., Garin D., Costagliola D., Autran B., Pantaleo G. and Bart P.-A.

NYVAC immunization induces polyfunctional HIV-specific T-cell responses in chronically-infected, ART-treated HIV patients Eur. J. Immunol. 2012, 42:3038-3048.

Haddad E.K. and Pantaleo G.

Systems biology in the development of HIV vaccines. Curr. Opin. HIV AIDS 2012, 7:44-49.

Enouz S., Carrié L., Merkler D., Bevan M.J. and Zehn D.

Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection. J. Exp. Med. 2012, 209:1769-1779.

Siegert S., Huang H.Y., Yang C.Y., Scarpellino L., Carrie L., Essex S., Nelson P.J., Heikenwalder M., Acha-Orbea H., Buckley C.D., Marsland B.J., Zehn D. and Luther S.A.

Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide. PLoS One 2011, 6:e27618.

Schaer C., Hiltbrunner S., Ernst B., Mueller C., Kurrer M., Kopf. M. and Harris N.L.

HVEM signalling promotes colitis. PLoS One 2011, 6:e18495.

Quakkelaar E.D., Redeker A., Haddad E.K., Harari A., McCaughey S.M., Duhen T., Filali-Mouhim A., Goulet J.P., Loof N.M., Ossendorp F., Perdiguero B., Heinen P., Gomez C.E., Kibler K.V., Koelle D.M., Sékaly R.P., Sallusto F., Lanzavecchia A., Pantaleo G., Esteban M., Tartaglia J., Jacobs B.L. and Melief C.J.

Improved innate and adaptive immunostimulation by genetically modified HIV-1 protein expressing NYVAC vectors. PLoS One 2011, 6:e16819.

Perreau M., Welles H.C., Harari A., Hall O., Martin R., Maillard M., Dorta G., Bart P.-A., Kremer E.J., Tartaglia J., Wagner R., Esteban M., Levy Y. and Pantaleo G.

DNA/NYVAC vaccine regimen induces HIV-specific CD4 and CD8 T-cell responses in intestinal mucosa. J. Virol. 2011, 85:9854-9862.

Miconnet I., Marrau A., Farina A., Taffé P., Vigano S., Harari A. and Pantaleo G.

Large TCR diversity of virus-specific CD8 T cells provides the mechanistic basis for massive TCR renewal after antigen exposure. J. Immunol. 2011, 186:7039-7049.

Herbst T., Sichelstiel A., Schär C., Yadava K., Bürki K., Cahenzli J., McCoy K., Marsland B.J. and Harris N.L.

Dysregulation of allergic airway inflammation in the absence of microbial colonization. Am. J. Respir. Crit. Care Med. 2011, 184:198-205.

Harris N.L.

Advances in helminth immunology: optimism for future vaccine design ? Trends Parasitol. 2011, 27:288-293.

Harris N. and Gause W.C.

To B or not to B: B cells and the Th2-type immune response to helminths. Trends Immunol. 2011, 32:80-88.

Harari A., Rozot V., Bellutti Enders F., Perreau M., Mazza Stalder J., Nicod L.P., Cavassini M., Calandra T., Lazor Blanchet C., Jaton C., Faouzi M., Day C.L., Hanekom W.A., Bart P.-A. and Pantaleo G.

Dominant TNF-α+ Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease. Nat. Med. 2011, 17:372-376.

Flynn B.J., Kastenmüller K., Wille-Reece U., Tomaras G.D., Alam M., Lindsay R.W., Salazar A.M., Perdiguero B., Gomez C.E., Wagner R., Esteban M., Park C.G., Trumpfheller C., Keler T., Pantaleo G., Steinman R.M. and Seder R.

Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates. Proc. Natl. Acad. Sci. USA 2011, 108:7131-7136.

Corey L., Nabel G.J., Dieffenbach C., Gilbert P., Haynes B.F., Johnston M., Kublin J., Lane H.C., Pantaleo G., Picker L.J. and Fauci A.S.

HIV-1 vaccines and adaptive trial designs. Sci. Transl. Med. 2011, 3:79ps13.

Cellerai C., Harari A., Stauss H., Yerly S., Geretti A.-M., Carroll A., Yee T., Ainsworth J., Williams I., Sweeney J., Freedman A., Johnson M., Pantaleo G. and Kinloch-de Loes S.

Early and prolonged antiretroviral therapy is associated with an HIV-1-specific T-cell profile comparable to that of long-term non-progressors. PLoS One 2011, 6:e18164.

Zehn D., Turner M.J., Lefrançois L. and Bevan M.J.

Lack of original antigenic sin in recall CD8(+) T cell responses. J. Immunol. 2010, 184:6320-6326.

Wilks A.B., Christian E.C., Seaman M.S., Sircar P., Carville A., Gomez C.E., Esteban M., Pantaleo G., Barouch D.H., Letvin N.L., and Permar S.R.

Robust vaccine-elicited cellular immune responses in breast milk following systemic Simian Immunodeficiency Virus DNA prime and live virus vector boost vaccination of lactating rhesus monkeys. J. Immunol. 2010, 185:7097-7106.

Pantaleo G., Esteban M., Jacobs B. and Tartaglia J.

Poxvirus vector-based HIV vaccines. Curr. Opin. HIV AIDS 2010, 5:391-396.

Létourneau S., van Leeuwen E.M., Krieg C., Martin C., Pantaleo G., Sprent J., Surh C.D. and Boyman O.

IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor alpha subunit CD25. Proc. Natl. Acad. Sci. USA 2010, 107:2171-2176.

Krieg C., Létourneau S., Pantaleo G. and Boyman O.

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells. Proc. Natl. Acad. Sci. USA 2010, 107:11906-11911.

Gerlach C., van Heijst J.W., Swart E., Sie D., Armstrong N., Kerkhoven R.M., Zehn D., Bevan M.J., Schepers K. and Schumacher T.N.

One naive T cell, multiple fates in CD8+ T cell differentiation. J. Exp. Med. 2010, 207:1235-1246.